“医学英语阅读：关节炎性疼痛综合征骨关节炎”相信是准备学习医学英语的朋友比较关注的事情，为此，医学教育网小编整理内容如下：

osteoarthritis has traditionally been described as“wear and tear”joint degeneration attributable to the aging process.pain due to osteoarthritis constitutes the most common joint complanint for which patien is seek medical attention.primary osteoarthritis affects the articular cartilage of otherwise normal joints.secondary osteoarthritis occurs as a sequela of trauma，joint disease such as legg-perthes disease，or subtle anomalies such as mild acetabular dysplasia resulting in long-standing joint incongruity.

骨关节炎被传统地描述为由于老年化过程而出现的磨损性关节变性。由骨关节炎引起的关节能疼痛是病人就医时最多的主诉。原发性骨关节炎犯其他正常侵犯其他正常的骨关节软骨面。继发性骨关节炎是作为创伤、关节病（如legg-perthe病）或轻微畸形（如轻度髋臼发育不良导致长期关节不交合）的后遗症而发生的。

osteoarthritis is the most common of all arthropathies，affecting roughly 30-50%of the entire population.heritability has not been demonstrated.women are more often affected than men，though virtually all persons overage 55 have some x-ray evidence of this disease.fortunately，less than half of patients with x-ray changes will experience joint symptoms.onset of symptomatic disease is usually in the sixth decade.

骨关节炎是所有骨关节病中最常见，整个人群中约有30~50%受累。遗传性未得到证实。女性较男性患者多。事实上超过55岁的人都有一点患此病的x线证据，幸而只有不到一半有x线证变化的病人感到有关节症状，通常是在60岁开始出现。

though the specific in citing agent remains unclear，the earliest histopathologic change in osteoarthritic joints is loss of mucopolysaccharide ground substance in the outermost layers of articular cartilage.as a result the mechanical properties of the cartilage are altered and resistance to deformation is lowered.the weakened superficial layers of cartilage develop fissures in response to increased deformation by normal loads.this results in uneven distribution of stress transmission to deeper layers of cartilage and to the underlying subchondral bone.this concentration of stress further accelerates cartilage wear with thinning of outer layers and propagation of cracks and fissures in the deeper layers.cartilage debris within the joint results in low-grade chronic inflammatory synovitis and joint effusion.

虽然特异性刺激因素尚不清楚，但是在骨关节炎关节中最早的组织病理学变化是在关节软骨的最外层中丧失粘液多糖基质。结果是软骨的机械性能发生改变，对变形的耐受力下降。变弱的表层软骨因对正常负荷增加变形而发生裂隙。这导致应力分布不均匀地传导至深层软骨及其下面的软骨下骨。集中的应有尽有力进一步加速外民支软骨磨损及变薄，也加速深层碎裂和裂隙的扩布。在关节内软骨碎片导致低度慢性囊炎和关节积液。

if weight bearing or stress loading of the affected joint continues，thinning of the cartilage may progress to eventual full-thickness cartilage loss.the subchondral bone bears progressively greater loads as cartilage destruction evolves.increased loading of bone stimulates bone remodeling and new bone deposition，manifested by marginal osteophyte formation and sclerosis within the overloaded subchondral bone incite a chronic inflammatory response replacement of nercrotic bone by fibrous tissue results in subchondral cyst formation.

如果受损的关节持续负重或承受应力，软骨变薄可进行下去，直到最后全层软骨消失。软骨破坏过程中，软骱下骨胳的负荷逐渐加重，骨负荷加重刺激骨胳重新塑和新骨沉积，表现为边缘的骨赘形成和软骨下骨质硬化。过度负荷的软骨下骨质中的细微骨折激起慢性炎症反应，坏死的骨骼被纤维组织替代导致软骨下囊肿形成。

以上是医学教育网小编整理的“医学英语阅读：关节炎性疼痛综合征骨关节炎”全部内容，想了解更多医学英语知识及内容，请点击医学教育网。